Name | Su5205 |
Synonyms | Su5205 SU5205 SU 5205 SU-5205 2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro- |
CAS | 3476-86-6 |
Molecular Formula | C15H10FNO |
Molar Mass | 239.24 |
Density | 1.306±0.06 g/cm3(Predicted) |
Melting Point | 194-196 °C |
Boling Point | 435.3±45.0 °C(Predicted) |
pKa | 12.69±0.20(Predicted) |
Storage Condition | 2-8°C |
In vitro study | SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC 50 of 5.1 μM. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.18 ml | 20.9 ml | 41.799 ml |
5 mM | 0.836 ml | 4.18 ml | 8.36 ml |
10 mM | 0.418 ml | 2.09 ml | 4.18 ml |
5 mM | 0.084 ml | 0.418 ml | 0.836 ml |
biological activity | SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with an IC50 of 9.6 µm. |
Target | Value |
VEGFR2 (Cell-free assay) | 9.6 μM |